1. Which of the following medications typically enhances immunologic activity?
   1. Glatiramer
   2. Methotrexate
   3. Cyclosporine
   4. Tacrolimus
   5. Sargramostim

ANS: E. Also known as “granulocyte-macrophage colony-stimulating factor” (GM-CSF), sargramostim enhances immunologic activity in patients suffering from deficiencies of these types of leukocyte.

1. Over the first 24 hours of glucocorticoid therapy, which group of leukocytes increases in number?
   1. Neutrophils
   2. Eosinophils
   3. Macrophages
   4. Basophils
   5. Lymphocytes

ANS: A. Glucocorticoids increase neutrophil count via enhanced release from the bone marrow.

1. This compound acts as an immunosuppressive drug via a DNA alkylating mechanism:
   1. Mycophenolate mofetil
   2. Tacrolimus
   3. Dexamethasone
   4. Infliximab
   5. Cyclophosphamide

ANS: E.

1. Which of the following effectively treats relapsing forms of multiple sclerosis, thereby decreasing the frequency of clinical exacerbations and delaying physical disability?
   1. INF-α
   2. INF-β
   3. INF-γ
   4. IL-2
   5. IL-11

ANS: B.

Wecker: Brody’s Human Pharmacology, 5th Edition

Chapter 07: Herbals and Natural Products

Test Bank

Multiple Choice

• The following is NOT a common safety issue with herbal medication:
  1. Adulteration
  2. Side effects
  3. Radioactivity
  4. Contamination
  5. Misidentification

ANS: C.

• Which of the following agents is marketed to decrease nausea and vomiting?
  1. Ginger
  2. Saw palmetto
  3. John’s wort
  4. Ginkgo biloba
  5. Kava

ANS: A.

• The following health claim has been approved by the Food and Drug Administration (FDA):
  1. Glucosamine may promote cartilage regeneration and slow the progression of arthritis.
  2. Garlic supplementation may reduce average blood pressure and LDL cholesterol.
  3. Echinacea may reduce the duration of cold and flu symptoms.
  4. Calcium supplementation may reduce the risk of osteoporosis.
  5. Antioxidant supplementation may slow neoplastic transformation in cancer patients.

ANS: D.