$35.00

**Chapter 7: Methods of Calculation for Individualized Drug Dosing**

**OTHER**

**Body Surface Area by Square Root**

- Order: cyclophosphamide 500 mg/m
^{2}in 500 mL of normal saline solution (NSS) over 90 minutes

Patient height and weight: 5 ft 10 in, 142 lb

Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL

- What is the patient’s body surface area (BSA) (m
^{2})? - What is the total dose?
- How many milliliters should you prepare?

ANS:

- 500 mg/m
^{2}´ 1.78 m^{2}= 890 mg

- FE: 890 mg/100 mg ´ 5 mL = 44.5 mL

**OR**

- Order: cisplatin 50 mg/m
^{2}in 500 mL of NSS intravenously over 90 minutes

Patient height and weight: 5 ft 6 in, 160 lb

Drug available: cisplatin 100 mg/100 mL

- What is the patient’s BSA (m
^{2})? - What is the total dose?
- How many milliliters should you prepare?

ANS:

b.50 mg ´ 1.83 m^{2} = 91.5 mg

- FE: 91.5 mg/100 mg ´ 100 mL = 91.5 mL or 92 mL

**OR**

**For Questions 3 through 18, use the square root method and/or nomogram. Note discrepancies between methods.**

- Give dacarbazine 250 mg/m
^{2}/day ´ 5 days.

Patient height: 5 ft 10 in

Patient weight: 173 lb

What is the daily dose with:

- square root method?
- nomogram?

ANS:

250 mg/m^{2}/day ´ 1.96 m^{2} = 490 mg/day

- Height 70 in, weight 173 lb, intersects 2.02 m
^{2}

250 mg/m^{2}/day ´ 2.02 m^{2} = 505 500 mg/day

- Give 5-fluorouracil 450 mg/m
^{2}/wk.

Patient height: 5 ft 6 in

Patient weight: 210 lb

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

450 mg/m^{2}/wk ´ 2.10 m^{2} = 945 mg/wk

- Height 66 in, weight 210 lb, intersects 2.04 m
^{2}

450 mg/m^{2}/wk ´ 2.04 m^{2} = 918 920 mg/wk

- Give leucovorin 200 mg/m
^{2}/wk.

Patient height: 5 ft 6 in

Patient weight: 210 lb

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

80 kg x 2.2 = 176 lb

200 mg/m^{2}/wk ´ 2.10 m^{2} = 420 mg/wk

- Height 66 in, weight 210 lb, intersects 2.04 m
^{2}

200 mg/m^{2}/wk ´ 2.04 m^{2} = 408.00 400 mg/wk

- Give cisplatin 30 mg/m
^{2}/day ´ 3 days.

Patient height: 70 in

Patient weight: 80 kg

What is the daily dose with:

- square root method?
- nomogram?

ANS:

- 80 kg ´ 2.2 = 176 lb

30 mg/m^{2}/day ´ 1.98 m^{2} = 59.4 59 mg/day

- Height 70 in, weight 80 kg, intersects 2.08 m
^{2}

30 mg/m^{2}/day ´ 2.08 m^{2} = 62.4 62 mg/day

- Give cisplatinum 80 mg/m
^{2}/wk.

Patient height: 6 ft 2 in

Patient weight: 186 lb

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

80 mg/m^{2}/wk ´ 2.09 m^{2} = 167.2 mg/wk

- Height 74 in, weight 186 lb, intersects 2.10 m
^{2}

80 mg/m^{2}/wk ´ 2.10 m^{2} = 168 170 mg/wk

- Give etoposide 120 mg/m
^{2}/wk.

Patient height: 74 in

Patient weight: 70 kg

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

- 70 kg ´ 2.2 = 154 lb

120 mg/m^{2}/wk ´ 1.90 m^{2} = 228 mg/wk

b.Height 74 in, weight 70 kg, intersects 2.06 m^{2}

120 mg/m^{2}/ wk ´ 2.06 m^{2} = 247.2 250 mg/wk

- Give Cytoxan 600 mg/m
^{2}/wk.

Patient height: 70 in

Patient weight: 85 kg

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

- 85 kg ´ 2.2 = 187 lb

600 mg/m^{2}/wk ´ 2.04 m^{2} = 1224 or 1225 mg/wk

- Height 70 in, weight 85 kg, intersects 2.08 m
^{2}

600 mg/m^{2}/wk ´ 2.08 m^{2} = 1248 1250 mg/wk

- Give Adriamycin 60 mg/m
^{2}/wk.

Patient height: 70 in

Patient weight: 80 kg

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

- 80 kg ´ 2.2 = 176 lb

60 mg/m^{2}/wk ´ 1.98 m^{2} = 118 mg/wk

- Height 70 in, weight 85 kg, intersects 2.08 m
^{2}

60 mg/m^{2}/wk ´ 2.08 m^{2} = 124.8 125 mg/wk

- Give vincristine 2 mg/m
^{2}/week.

Patient height: 62 in

Patient weight: 75 kg

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

- 75 kg ´ 2.2 = 165 lb

2 mg/m^{2}/wk ´ 1.80 m^{2} = 3.6 mg/wk

- Height 62 in, weight 75 kg, intersects 1.78 m
^{2}

2 mg/m^{2}/wk ´ 1.78 m^{2} = 3.56 3.6 mg/wk

- Give mitomycin 15 mg/m
^{2}/week.

Patient height: 65 in

Patient weight: 64 kg

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

- 64 kg ´ 2.2 = 140.8 or 141 lb

15 mg/m^{2}/wk ´ 1.71 m^{2} = 25.6 or 26 mg/wk

- Height 65 in, weight 64 kg, intersects 1.75 m
^{2}

15 mg/m^{2}/wk ´ 1.75 m^{2} = 26.25 26 mg/wk

- Give mitoxantrone 12 mg/m
^{2}/day ´ 3 days.

Patient height: 5 ft 8 in

Patient weight: 150 lb

What is the daily dose with:

- square root method?
- nomogram?

ANS:

12 mg/m^{2}/day ´ 1.80 m^{2} = 21.6 or 22 mg/day

- Height 68 in, weight 150 lb, intersects 1.85 m
^{2}

12 mg/m^{2}/day ´ 1.85 m^{2} = 22.2 22 mg/day

- Give cytosine arabinoside 100 mg/m
^{2}/day ´ 7 days.

Patient height: 5 ft 2 in

Patient weight: 130 lb

What is the weekly dose with:

- square root method?
- nomogram?

ANS:

100 mg/m^{2}/day ´ 1.6 m^{2} = 160 mg/day

- Height 62 in, weight 130 lb, intersects 1.65 m
^{2}

100 mg/m^{2}/day ´ 1.65 m^{2} = 165 mg/day

- Give methotrexate 3.3 mg/m
^{2}/day ´ 7 days.

Patient height: 72 in

Patient weight: 82 kg

What is the daily dose with:

- square root method?
- nomogram?

ANS:

- 82 kg ´ 2.2 = 180.4 lb

3.3 mg/m^{2}/day ´ 2 m^{2} = 6.6 mg/day

- Height 72 in, weight 82 kg, intersects 2.10 m
^{2}

3.3 mg/m^{2}/day ´ 2.10 m^{2} = 6.93 6.9 mg/day

- Give prednisone 60 mg/m
^{2}/day ´ 7 days.

Patient height: 72 in

Patient weight: 84 kg

What is the daily dose with:

- square root method?
- nomogram?

ANS:

- 84 kg ´ 2.2 = 184.8 or 185 lb

60 mg/m^{2}/day ´ 2.06 m^{2} = 123.7 or 124 mg/day

- Height 72 in, weight 84 kg, intersects 2.10 m
^{2}

60 mg/m^{2}/day ´ 2.10 m^{2} = 126 mg/day

- Give idarubicin hydrochloride 12 mg/m
^{2}/day ´ 3 days.

Patient height: 60 in

Patient weight: 60 kg

What is the daily dose with:

- square root method?
- nomogram?

ANS:

- 60 kg ´ 2.2 = 132 lb

12 mg/m^{2}/day ´ 1.59 m^{2} = 19.1 or 19 mg/day

- Height 60 in, weight 60 kg, intersects 1.60 m
^{2}

12 mg/m^{2}/day ´ 1.60 m^{2} = 19.2 19 mg/day

- Give cytarabine 100 mg/m
^{2}/day ´ 7 days.

Patient height: 64 in

Patient weight: 65 kg

What is the daily dose with:

- square root method?
- nomogram?

ANS:

- 65 kg ´ 2.2 = 143 lb

100 mg/m^{2}/day ´ 1.7 m^{2} = 170 mg/day

- Height 64 in, weight 60 kg, intersects 1.69 m
^{2}

100 mg/m^{2}/day ´ 1.69 m^{2} = 169 170 mg/day

- Order: streptozocin 1000 mg/m
^{2}in 100 mL D_{5}W over 2 hours

Patient’s height and weight: 5 ft 2 in and 210 lb

Drug available: streptozocin 1 g powdered vial, reconstitute with 9.5 mL NS; yields 100 mg/mL

- What is the patient’s BSA (m
^{2})? - What is the total dose?
- How many milliliters should you prepare?

ANS:

- 2.04 m
^{2}´ 1000 mg/m^{2}= 2040 mg

- Order: methotrexate 3 mg/m
^{2}PO ´ 2 weekly

Patient’s height and weight: 5 ft 2 in and 130 lb

Drug available: methotrexate tablets 2.5 mg, 5 mg, 7.5 mg

- What is the patient’s BSA (m
^{2})? - What is the total dose?

ANS:

- 1.6 m
^{2 }´ 3 mg/m^{2}= 4.80 mg or 5 mg tablet twice a week

- Order: sargramostim 250 mcg/m
^{2}/day, dilute in 50 mL and infuse over 2 hours

Patient’s height and weight: 5 ft 10 in and 215 lb

Drug available: sargramostim 500 mcg/mL

- What is the patient’s BSA (m
^{2})? - What is the total dose?
- How many milliliters should you prepare?

ANS:

- 2.52 m
^{2}x 250 mcg/m^{2}= 630 mcg

- Order: clofarabine 52 mg/m
^{2}daily and infuse in 250 mL D_{5}W over 2 hours

Patient’s height and weight: 5 ft 4 in and 115 lb

Drug available: 20 mg/20 mL

- What is the patient’s BSA (m
^{2})? - What is the total dose?
- How many milliliters should you prepare?

ANS:

- 1.53 m
^{2}´ 52 mg/m^{2}= 79.56 mg or 80 mg

**Chapter 8: Oral and Enteral Preparations with Clinical Applications****OTHER**- Order: HydroDIURIL 50 mg, PO, daily

Drugs available:

- Which bottle of HydroDIURIL would you use?
- How many tablets would you give? (Show your work.)

ANS:

- HydroDIURIL 25 mg bottle. (You could use HydroDIURIL 100 mg bottle, but the tablet should be scored and broken in half.)

*=*2 tablets**OR**Cross multiply: 25

*x*= 50*x*= 2 tablets**OR**RP: H : V :: D :

*x*25 : 1 :: 50 :

*x*25

*x*= 50*x*= 2 tablets**OR**(using 100 mg bottle)- Order: hydroxyzine pamoate 0.1 g, PO, q8h

Drugs available:

- Which bottle of hydroxyzine would you use? Explain.
- How many tablets/capsules would you give?

ANS:

- Vistaril is hydroxyzine pamoate.

Change 0.1 g to milligrams.

Cross multiply 100

*x*= 100*x*= 1 cap/tab**OR**RP: H

**:**V**::**D**:***x*100 mg

**:**1 tab**::**100 mg**:***x*tab100

*x =*100*x*= 1 cap/tab**OR**(conversion needed)DA:

- Order: aspirin gr X, PO, bid

Drug available:

- Gr X is equal to how many milligrams? (Use table if needed.)
- How many tablets would you give?

ANS:

- Gr X = 650 mg
- 2 tablets of aspirin per dose

- Order: amoxicillin clavulanate (Augmentin) 0.5 g, PO, q8h

Drugs available:

- Which bottle would you use?
- How many tablets would you give?

ANS:

- Either bottle; 0.5 g = 500 mg
- 2 tablets of Augmentin 250 mg; 1 tablet of Augmentin 500 mg

- Order: megestrol acetate (Megace) 160 mg, PO, in four divided doses

Drug available:

- How many milligrams should the patient receive per dose?
- How many tablets should the patient receive per dose?

ANS:

- 160 mg ÷ 4 times a day = 40 mg per dose

- Order: minocycline HCl 100 mg, PO, q12h

Drug available:

How many capsules would you give per dose?

ANS:

2 capsules

- Order: Nitrostat 0.6 mg, SL, stat

Drugs available:

- Which bottle of Nitrostat would you use?
- How many tablets would you give?

ANS:

- Nitrostat 0.3 mg sublingual (SL) tablet for Nitrostat tablets cannot be broken.
- 2 tablets SL

- Order: Nitrostat gr 1/100, SL, stat

Drug available:

- How many tablets would you give?
- Explain your answer.

ANS:

- None from this bottle.
- SL tablet cannot be broken.

- Order: carvedilol (Coreg) 12.5 mg, PO, bid

Drug available:

- How many tablets should the patient receive per dose?
- How many milligrams should the patient receive per day?

ANS:

- 2 tablets
- 25 mg per day

- Order: acebutolol (Sectral), 200 mg, PO, bid (twice a day)

Drugs available: acebutolol 100 mg, 200 mg, and 400 mg tablets

- Which acebutolol tablet you would select
- How many tablets would you give per dose per day?

ANS:

- 200 mg tablet strength
- 1 tablet per dose; 2 tablets per day

- Order: acyclovir (Zovirax) 200 mg, PO, 5 ´ a day

Drugs available: Zovirax 200 mg capsule; and 400 mg and 800 mg tablets

- Which Zovirax would you select?
- How many milligrams should the patient receive per day?
- How many tablets/capsules of Zovirax should be administered per dose?

ANS:

- 200 mg capsule
- 1000 mg per day
- 1 Zovirax 200 mg capsule

- Order: almotriptan (Axert) 12.5 mg PO, stat. May be repeated in 2 hours only.

Drug available: Axert 6.25 mg tablet

- How many tablets would you administer?
- If the dose is repeated in 2 hours, how many tablets should be given?

ANS:

- 2 tablets
- 2 tablets

- Order: amiloride (Midamor) 10 mg, PO, in two divided doses and may increase to 15 mg per day.

Drug available: amiloride 5 mg tablet

- How many tablets should the patient receive per dose?
- If the dose is increased, how many tablets should the patient receive per day?

ANS:

- 1 tablet per dose
- 3 tablets per day

- Order: aripiprazole (Abilify) 30 mg, PO, daily for 2 weeks; then 15 mg, PO, daily

Drugs available: Abilify, 10 mg, 15 mg, 20 mg, 30 mg tablets

- Which Abilify tablet would you select? Explain.
- How many tablet(s) daily would you give during the first 2 weeks?
- How many tablet(s) would you give daily after the first 2 weeks?

ANS:

- Either the 15 mg or 30 mg tablet. By selecting the 15 mg tablet, the same strength could be used after the first 2 weeks.
- 2 tablets of Abilify 15 mg or 1 tablet of the Abilify 30 mg tablet
- 1 tablet of Abilify 15 mg or tablet of the Abilify 30 mg tablet

- Order: captopril (Capoten) 75 mg, PO, bid

Drugs available: Capoten 12.5 mg, 25 mg, 50 mg, 100 mg tablets

- Which Capoten strength would you select? Why?
- How many milligrams should the patient receive per day?
- If selecting the 25 mg strength, how many tablets should the patient receive per dose?

ANS:

- Select 25 mg strength OR select 25 mg and 50 mg strength.
- 150 mg per day
- 3 tablets

- Order: cephalexin 0.5 g, PO, q6h

Drug available:

- How many milligrams equal 0.5 g?
- How many tablets would you give?

ANS:

- 2 tablets

- Order: cloxacillin 1 g/day, PO, in four divided doses, q6h

Drug available:

- How many milligrams should the patient receive q6h?
- How many capsules would you give per dose?

ANS:

- 1 g = 1000 mg; 1000 mg ÷ 4 = 250 mg, q6h
- 1 capsule of cloxacillin per dose

- Order: Cardizem SR 120 mg, PO, bid

Drugs available:

- Which bottle of Cardizem would you use?
- How many milligrams per day should the patient receive?
- How many tablets/capsules per dose would you give?

ANS:

- Cardizem SR
- 240 mg per day (bid means twice a day)
- 2 capsules of Cardizem SR per dose

- Order: Decadron 0.5 mg, PO, tid

Drug available:

- How many milligrams should the patient receive per day?
- How many tablets would you give per dose?

ANS:

- 1.5 mg of Decadron per day (tid means three times per day)

- Order: Cipro 0.5 g, PO, q12h

Drug available:

- How many tablets would you give per dose?
- How many milligrams would you give per day?

ANS:

- 1 tablet
- 1000 mg of Cipro per day

- Order: carbidopa-levodopa, 50 mg carbidopa/200 mg levodopa, PO, bid

Drug available: 25 mg carbidopa/100 mg levodopa ER tablet

How many ER tablets should the patient receive per dose?

ANS:

2 ER tablets per dose

- Order: chlorzoxazone (Paraflex) 750 mg, PO, tid

Drugs available: chlorzoxazone 250 mg and 500 mg tablet

- How many milligrams should the patient receive per day?
- Which chlorzoxazone strength would you select? Explain

ANS:

- 250 mg per day
- Select the 250 mg strength; give 3 tablets OR give one 250 mg tablet and one 500 mg tablet.

- Order: colesevelam (Welchol) 1250 mg, PO, bid with meals

Drug available: colesevelam 625 mg tablet

How many tablets should the patient receive per dose?

ANS:

2 tablets

- Order: doxazosin (Cardura) 0.5 mg, PO, at bedtime; increase as needed

Drugs available: doxazosin 1 mg, 2 mg, 4 mg, and 8 mg tablets

- Which doxazosin strength would you select?
- How many tablets would you give?

ANS:

- 1 mg doxazosin tablet strength
- tablet

- Order: procainamide (Procan) SR 0.5 g, PO, q6h

Drug available:

- How many grams should the patient receive per day?
- How many tablets of Procan will you give per dose?

ANS:

- 2 g per day
- 1 tablet of Procan SR per dose

- Order: Mandelamine 1 g, PO, q12h

Drug available:

How many tablets would you give?

ANS:

2 tablets of Mandelamine 0.5 g

- Order: methyldopa (Aldomet) 0.75 g, PO, bid

Drug available:

- How many grams of Aldomet should the patient receive per day?
- How many milligrams per day?
- How many tablets would you give per dose?

ANS:

- 1 g = 1000 mg; 1.5 g per day
- 1500 mg per day

- Order: digoxin (Lanoxin) 0.5 mg, PO, daily

Drugs available:

- Which bottle of digoxin (Lanoxin) would you use?
- How many tablets would you give?

ANS:

- Lanoxin 250 mcg (0.25 mg) bottle
- 2 tablets (or 4 tablets of 125 mcg bottle)

- Order: fenofibrate (Antara) 90 mg, PO, daily

Drugs available: Antara 45 mg, 87 mg, and 130 mg capsules

- Which Antara strength would you select?
- How many capsules would you give per day?

ANS:

- Antara 45 mg strength
- 2 capsules per day

- Order: bisoprolol (Zebeta) 5 mg, PO, for 4 weeks; increase to 10 mg for

the next 4 weeks and 15 mg after the last 4 weeks

Drug available:

- How many tablets would you give for the first 4 weeks?
- How many tablets would you give for the next 4 weeks?
- How many tablets would you give during the third 4 weeks?

ANS:

- 1 tablet
- 2 tablets
- 3 tablets

- Order: kanamycin 0.5 g, PO, q12h

Parameter: 15 mg/kg/day in two or three divided doses

Patient weighs 68 kg

Drug available:

- Is the patient’s daily dose within safe dose parameters? Explain.
- How many tablets would you give per dose?

ANS:

- Parameter: 15 mg ´ 68 kg = 1020 mg per day. Ordered dose is 1 g or 1000 mg per day, which is within safe dose parameters.
- 0.5 g = 500 mg; 1 capsule per dose

- Order: cefuroxime (Ceftin) 0.25 g, PO, bid

Drug available:

- How many milligrams equals 0.25 g?
- How many tablets would you give per dose?

ANS:

- 2 tablets of cefuroxime 125 mg per dose

- Order: ethambutol (Myambutal) 15 mg/kg/day, PO

Drugs available: Myambutal 100 mg and 400 mg tablets

Patient weight: 67 kg

- How many Myambutal should the patient receive per day?
- Which strength Myambutal would you select?
- How many tablets would you give?

ANS:

- 15 ´ 67 kg = 1005 mg or 1000 mg
- 400 mg strength
- 2.5 tablets per day

- Order: etodolac 1.2 g/day, PO, in three divided doses

Drug available: etodolac 200 mg capsules

- How many milligrams should the patient receive per dose?
- How many capsules would you give per dose?

ANS:

- 1.2 g = 1200 mg; 1200 ÷ 3 = 400 mg per dose
- 2 capsules of etodolac 200 mg per dose

- Order: Compazine 10 mg, PO, qid

Drug available:

(Maximum dose is 40 mg/day.)

- Is the dose per day within safe parameters? Explain.
- How many tablets would you give per dose?

ANS:

- Yes; 10 mg, qid = 40 mg per day (qid means 4 times a day)
- 2 tablets of Compazine per dose

- Order: glyburide 2.5 mg, PO, daily

Drugs available: Glyburide 1.25 mg and 5 mg

- Which bottle of glyburide would you use?
- How many tablets of glyburide would you give?

ANS:

- Either bottle of glyburide is OK, but the 1.25 mg bottle is preferred because it prevents breaking a 5-mg tablet in half.
- 2 tablets of glyburide 1.25 mg, or tablet of glyburide 5 mg

- Order: prazosin 4 mg, PO, tid

Drugs available: prazosin 1 mg, 2 mg, and 5 mg caplets

- Which bottle of prazosin would you use?
- How many capsules would you give per dose?

ANS:

- Prazosin 2 mg bottle

- Order: levothyroxine 25 mcg, PO, daily

Drugs available: levothyroxine 0.025 mg and 0.05 mg tablet

Change micrograms (mcg) into milligrams. Move the decimal point three spaces to the

*left*- 25 mcg = _____ mg
- Which levothyroxine tablet would you select?
- How many tablets would you give per day?

ANS:

- 0.025 mg

b.0.025 mg tablet

c.1 tablet

- Order: Nitrostat tablets

Drugs available:

- Which of these nitroglycerin preparations is most potent?
- How is Nitrostat SL administered? Why?

ANS:

- Nitrostat 0.6 mg or 1/100 gr
- SL (under the tongue); drug is absorbed by the sublingual vessels under the tongue because gastric juices destroy the drug.

- Order: pindolol 5 mg, PO, bid; after 2 weeks increase dose to 20 mg/day in two divided doses

Drugs available:

- How many tablets of pindolol should the patient receive per dose for the first 2 weeks?
- How many tablets of pindolol should the patient receive per dose after 2 weeks?

ANS:

- 1 tablet (5 mg bottle)
- 2 tablets (5 mg bottle); 1 tablet (10 mg bottle) per dose

- Order: ethambutol HCl 200 mg, PO, qid

Parameter: 15 mg/kg/day

Patient weighs 121 lb

Drugs available: ethambutol 100 mg and 400 mg

- How many kilograms does the patient weigh?
- What is the maximum dose the patient should receive per day?
- Which bottle of ethambutol would you use?
- How many tablets would you give?

ANS:

- 121 lb ÷ 2.2 kg = 55 kg
- 15 mg ´ 55 kg = 825 mg per day; dose is within safe dose parameter of 825 mg per day or 800 mg per day.
- Ethambutol 100 mg bottle
- 2 tablets from ethambutol 100 mg bottle per dose.

- Order: aminocaproic acid (Amicar) 1.5 g, PO, stat, and may repeat in 1 hour

Drug available:

- How many milligrams are in 1.5 g?
- How many tablets would you give?

ANS:

- 3 tablets of aminocaproic acid from Amicar 500 mg bottle

- Order: capecitabine (Xeloda) 2500 mg/m
^{2}/day in two divided doses

Patient height: 64 in; weight 160 lb

Drugs available: Xeloda 150 mg and 500 mg tablets

- Using the nomogram, what is the BSA or m
^{2}? - Patient should receive how many mg per day and per dose?
- Which of the Xeloda strengths would you use?
- How many tablets should the patient receive per dose?

ANS:

- BSA 1.8
- 4500 mg per day; 2250 mg per dose
- Select Xeloda 500 mg strength.
- 4days per day using the 500 mg strength

- Order: mercaptopurine (6-MP), 80 mg/m
^{2}/day, PO

Patient BSA (m

^{2}) is 1.8Drug available: mercaptopurine 50 mg tablets

- How many milligrams should the patient receive per day?
- How many tablets should the patient receive per day

ANS:

- 144 mg per day
- 2.88 tablets or 3 tablets (round off) per day

- Order: timolol maleate (Blocadren) 10 mg, PO, bid; then, after 2 weeks, the patient is to receive 40 mg in two divided doses

Drugs available:

- Which bottle of Blocadren would you choose for the first 2 weeks?
- How many tablets should the patient receive per dose during the first 2 weeks?
- Which bottle of Blocadren would you choose after the first 2 weeks? Why?
- How many tablets should the patient receive per dose after the second week?

ANS:

- Blocadren 10 mg
- 1 tablet of Blocadren of 10 mg
- Blocadren 20 mg; fewer tablets to give
- 1 tablet of Blocadren of 20 mg

- Order: codeine gr 1, PO, stat

Drug available:

How many tablets of codeine would you give?

ANS:

- Order: propranolol (Inderal) 30 mg, PO, tid

Drugs available: propranolol 10 mg, 20 mg, 40 mg, 60 mg, and 80 mg

- Which bottle(s) of propranolol would you use?
- How many tablets would you give per dose?

ANS:

- Propranolol 10 mg and 20 mg bottles
- 1 tablet from each bottle per dose (could use the 60 mg bottle and give tablet)

- Order: Tagamet 0.4 g, PO, bid, and 0.8 g, at hour of sleep

Drugs available:

- Which bottle of Tagamet would you use?
- How many tablets would you give per dose during the day? How many tablets at hour of sleep?

ANS:

- 0.4 g = 400 mg; either bottle is OK, but Tagamet 400 mg is preferred.
- Using a Tagamet 400 mg bottle, give 1 tablet per dose during the day and 2 tablets at night (hs). Using a Tagamet 200 mg bottle, give 2 tablets per dose during the day and 4 tablets at night.

- Order: cinoxacin 1 g/day, PO, in two divided doses

Drugs available: cinoxacin 250 mg and 500 mg capsules

- What are the specific times for the patient to receive cinoxacin?
- How many grams or milligrams per dose?
- Which bottle of cinoxacin would you use?
- How many capsules would you give?

ANS:

- Two divided doses q12h
- 0.5 g or 500 mg per dose
- Either bottle is OK, but cinoxacin 500 mg is preferred.
- Using the cinoxacin 500 mg, give 1 capsule per dose; using cinoxacin 250 mg, give 2 capsules per dose.

- Order: captopril (Capoten) 50 mg, PO, bid

Drugs available: captopril 12.5 mg, 25 mg, and 37.5 mg tablets

- Which bottle of captopril would you use?
- How many tablets would the patient receive per dose?

ANS:

- Captopril 25 mg bottle
- 2 tablets of captopril per dose

- Order: moxifloxacin (Avelox) 400 mg, PO, daily for 5 days; then 200 mg

PO, daily for the next 5 days.

Drug available:

- How many tablets would you give for the first 5 days?
- How many tablets would you give for the next 5 days?

ANS:

- 1 tablet of Avelox
- tablet of Avelox

- Order: amlodipine (Norvasc) 2
**.**5 mg, PO, daily and increase to 5 mg daily.

Drugs available: Norvasc 5 mg and 10 mg tablets

- Which Norvasc strength would you select?
- How many tablets would you give for 2.5 mg?
- With an increase dosage of 5 mg, how many tablets would you give?

ANS:

- Select the Norvasc 5 mg strength.
- tablet of Norvasc for 2.5 mg
- 1 tablet of Norvasc

- Order: pravastatin (Pravachol) 20 mg, PO, at bedtime

Drug available:

How many tablets would you give?

ANS:

2 tablets

- Order: betamethasone (Celestone) 2.4 mg, PO, daily

Drug available: betamethasone 0.6 mg tablets

How many tablets would you give?

ANS:

- Order: dexamethasone (Decadron) 3 mg, PO, bid

Drugs available:

- Which bottle of Decadron would you use?
- How many tablets would you give per dose?

ANS:

- Decadron 1.5 mg bottle
- 2 tablets per dose (or if the 6.0 mg tablet is scored, you can break the tablet in half and give tablet)

- Order: Dilantin 0.1 g, PO, daily

Drugs available: phenytoin (Dilantin) 30 mg and 100 mg capsules

- Which bottle of Dilantin would you use?
- How many capsules of Dilantin would you give?

ANS:

- 1 capsule from phenytoin 100 mg bottle

- Order: phenytoin (Dilantin) 1 g, PO, loading dose (LD) in three divided doses in 24 hours

Parameter: 15 to 18 mg/kg/LD

Patient weighs 60 kg

Drug available: Dilantin 100 mg capsule

- In 24 hours, three divided doses would be how often?
- How many milligrams would the patient receive per dose in 24 hours?
- Is the dose within safe parameters? Explain.
- How many capsules would you give per dose?

ANS:

- 8 hours (q8h)
- Per dose: (1) 300 mg, (2) 300 mg, and (3) 400 mg
- Yes, the dose is within safe dose parameters (900-1080 mg). Parameters: 15 mg ´ 60 = 900 mg; 18 mg ´ 60 = 1080 mg.
- (1) 3 capsules, (2) 3 capsules, and (3) 4 capsules

- Order: meprobamate (Equanil) 1.2 g/day, in three divided doses

Drugs available: Equanil 200 mg and 400 mg tablets

- How many milligrams would the patient receive per dose?
- Which bottle of meprobamate would you use?
- How many tablets would you give per dose?

ANS:

- 1.2 g = 1200 mg; 1200 ÷ 3 = 400 mg per dose
- Either bottle is OK, but meprobamate 400 mg bottle is preferred.
- 1 tablet per dose from meprobamate 400 mg bottle

- Order: cyclophosphamide (Cytoxan) 200 mg, PO, daily

Parameter: 1 to 5 mg/kg/day

Patient weighs 100 lb

Drug available:

- How many kilograms does the patient weigh?
- Is the dose of Cytoxan within the parameter range? Explain.
- How many tablets would you give?

ANS:

- 100 lb ÷ 2.2 = 45.5 kg
- 1 mg ´ 45.5 = 45.5 mg; 5 mg ´ 45.5 = 227.3; Yes; dose is within safe parameters.
- 4 tablets of Cytoxan per dose

- Order: Dilantin 100 mg, PO, daily

Drug available: Dilantin 250 mg per 5 mL

How many milliliters would you give?

ANS:

- Order: escitalopram (Lexapro) 7.5 mg, PO in the AM daily

Drug available: Lexapro 5 mg/5 mL

How many milliliters would you give in the AM?

ANS:

7.5 mL in the AM

- Order: famotidine (Pepcid) 40 mg, PO, bedtime for 4 weeks, then 20 mg

at bedtime for the next 4 weeks

Drug available: Pepcid 40 mg/5 mL

- How many milliliters should the patient receive at bedtime for the first 4 weeks?
- How many milliliters should the patient receive at bedtime for the next 4 weeks?

ANS:

- 5 mL for the first 4 weeks
- 2or 2.5 mL for the second 4 weeks

- Order: fluphenazine HCl (Prolixin) 5 mg, PO, q6h

Drug available: fluphenazine HCl 2.5 mg/5 mL

- How many milligrams should the patient receive per day?
- How many milliliters should the patient receive per dose?

ANS:

- 20 mg per day
- 10 mL per dose

- Order: amoxicillin 200 mg, PO, q8h

Drug available:

How many milliliters of amoxicillin would you give per dose?

ANS:

4 mL of amoxicillin per dose

- Order: Artane 1 mg, PO initially

Drug available:

How many milliliters would you give initially?

ANS:

- Order: Artane 5 mg, PO, bid

Drug available:

How many milliliters of Artane would you give per dose?

ANS:

- Order: minocycline (Minocin) 100 mg, PO, q12h

Drug available:

How many milliliters would you administer per dose?

ANS:

10 mL of minocycline per dose

- Order: ampicillin (Principen) 150 mg, PO, q6h

Drug available:

How many milliliters of ampicillin would you give?

ANS:

- Order: doxycycline monohydrate (Vibramycin) 100 mg, PO, initially; then 100 mg, PO, in two divided doses per day

Drug available:

- How many milliliters should the patient receive initially?
- How many milligrams should the patient receive per dose after the initial dose?
- How many milliliters should the patient receive per dose after the initial dose?

ANS:

- 20 mL initially
- 50 mg
- 10 mL

- Order: potassium chloride 30 mEq, PO, daily with food

Drug available: potassium chloride 20 mEq/15 mL

How many milliliters of potassium chloride would the patient receive?

ANS:

- Order: docusate sodium (Colace) 200 mg, PO, daily per nasogastric tube

Drug available: Colace 50 mg/5 mL

How many milliliters of Colace would the patient receive?

ANS:

20 mL of Colace per day

RP: H : V :: D :

*x*50 mg : 5 mL :: 200 mg :

*x*50

*x*= 1000*x*= 20 mL- Order: azithromycin (Zithromax) 300 mg, PO, first day, then 160 mg, PO, per day for the second through the fifth days

Drug available:

- How many milliliters should the patient receive the first day?
- How many milliliters should the patient receive per dose for the next 4 days?

ANS:

- 7.5 mL first day

- Order: cefuroxime axetil (Ceftin) 350 mg, PO, bid

Drug available:

- How many milligrams should the patient receive per day?
- How many milliliters should the patient receive per dose?

ANS:

- 700 mg of Ceftin per day
- 7 mL per dose

- Order: cefadroxil (Duricef) 1 g/day, PO, in two divided doses

Drugs available:

- How many milligrams would the patient receive per dose?
- Which bottle of Duricef would you use?
- How many milliliters would you give per dose?

ANS:

- 500 mg per dose
- Either bottle is OK, but Duricef 500 mg/5 mL bottle is preferred.
- Using Duricef 500 mg/5 mL bottle, give 5 mL per dose; using Duricef 250 mg/5 mL, give 10 mL per dose.

- Order: Cephalexin 0.5 g, PO, q6h

Drug available:

How many milliliters would the patient receive per dose? (Convert grams to milligrams.)

ANS:

0.5 g = 500 mg; thus, give 10 mL of cephalexin per dose

- Order: prochlorperazine (Compazine) 7.5 mg, PO, qid

Drug available:

How many milliliters of Compazine would the patient receive per dose?

ANS:

7.5 mL of Compazine per dose

- Order: cyproheptadine 4 mg, PO, tid

Drug available: cyproheptadine 2 mg/5 mL syrup

- How many milligrams should the patient receive per day?
- How many milliliters should the patient receive per dose?

ANS:

- Patient should receive 12 mg per day.
- Cyproheptadine 10 mL per dose

- Order: donepezil (Aricept) 5 mg, PO, daily at bedtime

Drug available: Aricept 1 mg/ mL oral liquid

How many milliliters should the patient receive at bedtime?

ANS:

5 mL of Aricept at bedtime

- Order: esomeprazole (Nexium) 20 mg, PO, per day

Available: Nexium oral suspension powder, 40 mg, mixed with 10 mL

How many milliliters would you give the patient per day?

ANS:

5 mL of Nexium oral solution per day

- Order: chlorpromazine (Thorazine) 25 mg, PO, qid

Drug available:

How many milliliters of Thorazine would the patient receive per dose?

ANS:

- Order: theophylline 120 mg, PO, daily

Drug available: theophylline elixir 80 mg/15 mL

How many milliliters of theophylline would you give?

ANS:

Give 22.5 mL of theophylline per day.

- Order: theophylline 5 mg/kg, PO, loading dose

Patient weight: 55 kg

Drug available: theophylline elixir 50 mg/5 mL

How many milliliters of theophylline would you give?

ANS:

Loading dose is 275 mg according to weight, so give 27.5 mL of theophylline as a loading dose.

5 mg ´ 55 kg = 275 mg

RP : H : V :: D :

*x*50 mg : 5 mL :: 275 mg :

*x*50

*x*= 1375*x*= 27.5 mL**OR**DA:

- Order: amoxicillin/clavulanate (Augmentin) 0.25 g, PO, q8h

Drug available:

How many milliliters of Augmentin would you give per dose?

ANS:

0.25 g = 250 mg; thus, give 10 mL of Augmentin per dose.

- Order: ampicillin 0.5 g, PO, q8h

Drug available:

How many milliliters of ampicillin would you give per dose?

ANS:

0.5 g = 500 mg; thus, give 10 mL of ampicillin per dose.

- Order: methyldopa (Aldomet) 400 mg, PO, bid

Drug available:

How many milliliters would you give per dose?

ANS:

8 mL of Aldomet per dose

- Order: albuterol 4 mg, PO, tid

Drug available: albuterol 2 mg/5 mL

How many milliliters of albuterol would you give per dose?

ANS:

- Order: cimetidine (Tagamet) 200 mg, PO, qid with meals

Drug available:

How many milliliters of Tagamet would you give?

ANS:

- Order: potassium chloride (KCl) 15 mEq, PO, bid

Drug available: potassium chloride 10 mEq/15 mL

- How many milliliters of KCl would you give per dose?
- How many milliequivalents (mEq) of KCl would the patient receive per day?
- How many milliliters of KCl per day?

ANS:

- 22.5 mL of potassium chloride per dose
- 30 mEq of KCl per day
- 45 mL of KCl per day

- Order: furosemide (Lasix) 30 mg, PO, bid

Drug available: furosemide 8 mg/mL

How many milliliters of furosemide would you give?

ANS:

3.75 mL of furosemide per dose

- Order: acyclovir (Zovirax) 400 mg, PO, bid

Drug available:

How many milliliters of Zovirax would you give per dose?

ANS:

10 mL of Zovirax per dose

- Order: diphenhydramine 50 mg, PO, q6h

Drug available: diphenhydramine 12.5 mg/5 mL

How many milliliters of diphenhydramine would you give per dose?

ANS:

20 mL of diphenhydramine per dose

- Order: lactulose 30 g, PO, tid

Drug available: lactulose 10 g/15 mL

How many milliliters of lactulose would you give per dose?

ANS:

45 mL of lactulose per dose

- Order: guaifenesin 400 mg, PO, q4h ´ 5 days or until cough subsides

Drug available: guaifenesin 100 mg/5 mL

How many milliliters of guaifenesin would you give per dose?

ANS:

20 mL of guaifenesin per dose

- Order: ondansetron (Zofran 5 mg, PO, 30 minutes before narcotic administration

Drug available:

How many milliliters would you give before narcotic administration?

ANS:

Cross multiply 4

*x*= 25*x*= 6. 25 or 6 mL (rounded off) 30 minutes before narcotic- Order: paroxetine (Paxil) 20 mg, PO, daily

Drug available: Paxil oral suspension 10 mg/5 mL

How many milliliters would you give per day?

ANS:

10 mL of Paxil

- Order: promethazine 25 mg, PO, bid

Drug available: promethazine 6.25 mg/5 mL

How many milliliters of promethazine would you give per dose?

ANS:

- Order: erythromycin 2 g/day in four divided doses

Drug available:

- Four divided doses would be equivalent to every _____ hours.
- How many milligrams would the patient receive per dose?
- How many milliliters of erythromycin would you give per dose?

ANS:

- 6 hours (q6h)
- 2 g = 2000 mg ÷ 4 = 500 mg per dose
- 10 mL of erythromycin per dose

- Order: clindamycin 300 mg, PO, q8h

Drug available: clindamycin 75 mg/mL

How many milliliters of clindamycin would you give per dose?

ANS:

4 mL of clindamycin per dose

- Order: nystatin (Mycostatin) 0.5 million units, qid, swish and swallow

Drug available:

How many milliliters of Mycostatin per dose would you pour?

ANS:

0.5 million units = 500,000 units; thus, give 5 mL of Mycostatin per dose.

- Order: Crestor 10 mg, PO, daily with evening meal

Drugs available:

- Which Crestor bottle would you select?
- How many tablets would you give?

ANS:

- Either Crestor bottle could be selected; the Crestor 10 mg bottle is preferred.
- Give 2 tablets of Crestor from the 5 mg bottle. If the Crestor 10 mg bottle is used, then give 1 tablet.

- Order: zidovudine (Retrovir) 100 mg by nasogastric tube, q6h

Drug available:

- How many milligrams should the patient receive per day?
- How many milliliters would you give per dose?

ANS:

- 400 mg per day of zidovudine
- 10 mL per dose of zidovudine

- Order: lamivudine (Epivir) 0.15 g, PO, bid

Drug available:

- How many milligrams should the patient receive per day?
- How many milliliters should the patient receive per dose?

ANS:

- 15 mL per dose of lamivudin

Only ** 0 ** units of this product remain